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Average systemic and ocular parameters in db/db and db/m mice from 8 to 20 weeks of age. Significant increases were observed in body weight ( A ) and blood glucose ( B ) in db/db mice (n = 6) compared with nondiabetic db/m mice (n = 6) by two-way repeated measures ANOVA. In contrast, no significant differences were observed in systemic blood pressure ( C ), mean arterial blood pressure ( D ), intraocular pressure ( E ), and ocular perfusion pressure ( F ) between two animal groups during follow-up period. Data are expressed as the mean ± SEM; au = arbitrary unit; *P < 0.05 between groups; NS = not significant between groups.

Journal: Scientific Reports

Article Title: Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice

doi: 10.1038/s41598-021-97651-3

Figure Lengend Snippet: Average systemic and ocular parameters in db/db and db/m mice from 8 to 20 weeks of age. Significant increases were observed in body weight ( A ) and blood glucose ( B ) in db/db mice (n = 6) compared with nondiabetic db/m mice (n = 6) by two-way repeated measures ANOVA. In contrast, no significant differences were observed in systemic blood pressure ( C ), mean arterial blood pressure ( D ), intraocular pressure ( E ), and ocular perfusion pressure ( F ) between two animal groups during follow-up period. Data are expressed as the mean ± SEM; au = arbitrary unit; *P < 0.05 between groups; NS = not significant between groups.

Article Snippet: The 7-week-old male C57BL/KsJ-db/db mice (BKS.Cg-Dock7 m +/+Lepr db /J; n = 6) and db/m (congenic nondiabetic littermates, n = 6) control mice were acquired from Charles River Laboratories JAPAN, Inc. (Yokohama, Japan) one week before the study.

Techniques: